• We have previously shown that

  2024-01-12

  

  We have previously shown that the human gonadotropins hLH and hCG trigger a partly irreversible stimulation of intracellular cyclic AMP accumulation in mouse Leydig Tumor Go 6983 (MLTC) in contrast to all other tested mammalian LHs and CG (Klett et al., 2016). In order to get a better insight in th

• br Results br Discussion Utilizing a

  2024-01-12

  

  Results Discussion Utilizing a proteomic approach, we identified HSP90β as a protein that becomes associated with surface AChR in agrin-stimulated muscle cells. We demonstrate that HSP90β does not interact with the AChR directly; instead, via direct interaction with rapsyn, HSP90β becomes asso

• br Disclaimer br Conflicts of interest br Role

  2024-01-12

  

  Disclaimer Conflicts of interest Role of the Sponsor Acknowledgements Funding/support: This project was supported by a grant from the Department of Surgery (R5129), Western University and by the Institute for Clinical Evaluative Sciences (ICES) Western site. ICES is funded by an annual

• HT modulates cortical and hippocampal pyramidal cell functio

  2024-01-12

  

  5-HT modulates cortical and hippocampal pyramidal cell function in a very complex manner, since most 5-HT receptor subtypes (excitatory as well as inhibitory) are expressed on pyramidal Florfenicol mg as well as GABAergic interneurons that exert inhibitory control over pyramidal cells (Leiser et al

• We demonstrate a role for low

  2024-01-12

  

  We demonstrate a role for low oxygen to regulate ATX mRNA in hepatocyte-derived HuH7 PF-00562271 and human liver slices, consistent with reports of increased ATX expression in a variety of tumours that are frequently hypoxic. Importantly, we show a positive association between elevated ATX mRNA lev

• ATM is generally regarded to be

  2024-01-11

  

  ATM is generally regarded to be the principal mediator of the G1 SJ 172550 checkpoint, whereas the induction of the intra-S-phase and G2/M checkpoints are usually primarily related to ATR function. However, several studies have demonstrated that, depending on the cellular context and type of DNA dam

• br Acknowledgements M M M is the William

  2024-01-11

  

  Acknowledgements M.M.M. is the William Dow Lovett Professor of Neurology and is supported by grants from the Michael J. Fox Foundation for Parkinson's Research, the American Parkinson Disease Association, the New Jersey Health Foundation/Nicholson Foundation, and by the National Institutes of He

• The mitochondrial protein AIF was the first caspase independ

  2024-01-11

  

  The mitochondrial protein AIF was the first caspase-independent death effector. AIF can induce caspase-independent chromatin condensation and large-scale DNA fragmentation to approximately 50 KB. AIF that is released to cytoplasm can mediate apoptosis when special extracellular signals trigger the o

• Overall the expression of both components

  2024-01-11

  

  Overall, the expression of both components (ligand and receptor) of the apelin signaling system allows for analysis of the direct role of apelin in CL function, and specifically P4 production. Although the CL secretes many different hormones, P4 is of predominant importance because it is necessary f

• Dopaminergic neurons are vulnerable to oxidative products an

  2024-01-11

  

  Dopaminergic neurons are vulnerable to oxidative products and inflammatory responses; these processes may play important roles in the etiology of PD. Because glial Caspase Inhibitor Set I mg are the main generators of inflammatory responses in the CNS, the possibility that PD results from glial cel

• Over expression of the inflammatory cytokines MMPs

  2024-01-11

  

  Over expression of the inflammatory cytokines, MMPs and COX-2 act as an important inducer of chronic inflammation. COX-2 catalyzes the biosynthesis of prostaglandins (PGs), and induced expression was observed in ion channel stimulated with pro-inflammatory cytokines or bacterial lipopolysaccharide (

• br Experimental procedures br Results

  2024-01-11

  

  Experimental procedures Results Discussion Our biophysical and cellular analyses of mutant Aβ1–42 peptides support a role of the N-terminus of Aβ in peptide aggregation and toxicity. We demonstrate that double mutations constructed to humanize the rodent Aβ1–42 sequence result in a signific

• MD was the recipient of the Intergroupe Francophone

  2024-01-11

  

  MD was the recipient of the Intergroupe Francophone de Cancérologie Thoracique (IFCT) Alain Depierre Grant in 2014. JP was the recipient of the ARISTOT (Association de Recherche, d’Information Scientifique et Thérapeutique en Oncologie Thoracique) grant in 2016. Conflicts of interest statement

• Octreotide acetate Two cell surface trans membrane receptors

  2024-01-11

  

  Two cell-surface trans-membrane receptors have been identified for adiponectin, AdipoR1 and AdipoR2 [21], and adiponectin action is known to signal through these receptors and the docking protein APPL1 [22]. In muscle and liver cells, signal transduction involves the phosphorylation and activation o

• br Materials and methods br Results br Discussion

  2024-01-11

  

  Materials and methods Results Discussion In the present study, we aimed to elucidate the contribution of adenosine receptors to vascular tone in mice with T1D. We showed that diabetes resulted in decreased A1 adenosine receptor-mediated contraction in the aorta, which was accompanied by inc

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