• Etoposide VP a semisynthetic podophyllotoxin derivative

  2022-08-09

  

  Etoposide (VP-16), a semisynthetic podophyllotoxin derivative agent, is widely used as a chemotherapic treatment for many cancers (Hande, 1998). VP-16 has been known that its activity is mediated by the interaction with topoisomerase II (an ATP-dependent nuclear enzyme) which regulates DNA topology

• Dacarbazine Initial evidence that cell contact mediated

  2022-08-09

  

  Initial evidence that cell-contact-mediated transmission of HIV-1 is relevant for the generation of latently infected Dacarbazine was suggested in the context of transmission from dendritic cells to resting CD4+ T cells (Evans et al., 2013, Kumar et al., 2015). As dendritic cells probe for antigens

• One of the possible disadvantages of this

  2022-08-09

  

  One of the possible disadvantages of this methodology is a possible cytotoxic effect resulting from either adenoviral vector injection or to Cre recombinase expression. Adenovirus has previously been used to efficiently mediate transgene expression in mouse angiopoietin (Thomas et al., 2000, Xia et

• Studies of human and mouse GPR as

  2022-08-09

  

  Studies of human and mouse GPR84, as ascertained by mRNA levels in various tissues, have determined that GPR84 is highly expressed on bone marrow cells, splenic T and B cells, and circulating granulocytes/monocytes/macrophages. In the latter cells, mRNA expression of is up-regulated only under infl

• br Introduction Depression is a prevalent and

  2022-08-09

  

  Introduction Depression is a prevalent and disabling psychiatric illness that affects millions of individuals worldwide, resulting in enormous personal suffering and public health costs [1]. Traditional antidepressants such as monoamine oxidase inhibitors (MAOIs) and selective serotonin reuptake

• br Introduction Glucose is the major carbon source

  2022-08-09

  

  Introduction Glucose is the major carbon source in most organisms. Cancer Birinapant in particular require a steady source of energy to maintain growth and proliferation, and preferentially use glycolysis for their energy supply even under aerobic conditions. Glucose uptake in mammals is mainly m

• A localization of GK to both

  2022-08-09

  

  A localization of GK to both a cytoplasmic and perinuclear area of normal rat pancreatic beta-cells was reported in 1996 (Noma et al., 1996), which changed on acute hyperglycemia to a more diffuse staining throughout the cytoplasm. The localization of GK within the nucleus was first reported by Mura

• Recently several dual GLP GIP receptor agonists have

  2022-08-09

  

  Recently, several dual GLP-1/GIP receptor agonists have been developed as a treatment of type II diabetes. These peptides can activate both the GLP-1 and the GIP receptor. Such dual receptor agonists are superior compared to single GLP-1 analogues such as liraglutide (Finan et al., 2013). Previously

• br The Farnesoid X receptor FXR identification and ligands

  2022-08-08

  

  The Farnesoid X receptor (FXR): identification and ligands The Farnesoid X receptor (FXR) belongs to a family of proteins called Nuclear Receptors (NRs). NRs are a class of ligand-activated transcription factors, which transactivate networks of target genes, thereby mediating a wide range of phys

• br Short Communication Free fatty acid receptors FFAR play s

  2022-08-08

  

  Short Communication Free fatty Alda 1 synthesis receptors (FFAR) play significant roles in energy metabolism (Brown et al., 2005; Ichimura et al., 2009). The receptor FFAR1 is involved in insulin secretion in humans (Meidute Abaraviciene et al., 2013). Activation of the receptor FFAR2 increases l

• Interestingly we have shown that

  2022-08-08

  

  Interestingly, we have shown that OA required FFAR4 to induce osteoblast gene expression in MC3T3-E1 pre-osteoblasts, but not to inhibit osteoclastogenesis in RAW264.7 murine macrophages. As previously suggested, FFAR1 may mediate the effects of OA in osteoclasts. However, FFAR1 has also been shown

• br Acknowledgments This study was

  2022-08-08

  

  Acknowledgments This study was supported by a Conquer Cancer Foundation (American Society for Clinical Oncology) Drug Development Research Professorship Grant (AAA). Introduction Gastric cancer (GC) is one of difficult cancers to treat in terms of its poor prognosis and limited applicability

• Receptor activator of NF B ligand RANKL and

  2022-08-08

  

  Receptor activator of NF-κB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) stimulate the generation of osteoclast PF 04418948 [10], [11], [12], [13]. In response to sphingosine 1-phosphate (S1P) signaling, osteoclasts then attach to regions of bone undergoing resorption [14]. In RA

• Our observation of LPS induced increase in

  2022-08-08

  

  Our observation of LPS-induced increase in the sensitivity of cultured endothelium-intact coronary Tubastatin A HCl towards stimulation with selective ETB receptor agonist (S6c) could be explained by activation of TLRs receptors located on the endothelium of rat coronary arteries. However, the poss

• FoxM a downstream target of Gli has been

  2022-08-05

  

  FoxM1, a downstream target of Gli, has been mainly related to E6 Berbamine regulation and cellular proliferation in tumor (Alvarez-Fernandez and Medema, 2013, Halasi and Gartel, 2013, Teh et al., 2002). Especially, FoxM1 is a regulator of G1/S and G2/M transitions and M-phase progression (Wonsey & F

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