• So far GnRH receptors have been detected

  2022-05-20

  

  So far, GnRH receptors have been detected in the human ovary, but their physiological importance is still unclear (). In particular, GnRH receptors as well as GnRH types I and II have been localized in the granulosa 22 9 of pre-ovulatory follicles, but not of follicles from the primordial to the ear

• br GluR A knockout mice Genetically modified

  2022-05-19

  

  GluR-A knockout mice Genetically modified, adult mice lacking the GluR-A AMPA receptor subunit exhibit fast synaptic transmission in the hippocampus, mediated by the receptors formed from the remaining AMPA receptor subunits GluR-B and GluR-C (Sommer et al., 1991), but are deficient in a rapidly

• Bacterial GluRS comes in two flavors discriminatory GluRS D

  2022-05-19

  

  Bacterial GluRS comes in two flavors, discriminatory GluRS (D-GluRS) and non-discriminatory GluRS (ND-GluRS). While D-GluRS exclusively catalyses the transfer of Glu to tRNAGlu, the ND-GluRS can also glutamylate tRNAGln forming Glu-tRNAGln. The misacylated product is then transformed to Gln-tRNAGln

• br Vertebrate steroid receptor evolution br

  2022-05-19

  

  Vertebrate steroid receptor evolution Conclusion The teleost WGD event resulted in the duplication of the vertebrate GR and MR and two GRs have been retained in the majority of teleost fish studied so far. The molecular basis for this retention has yet to be fully understood. The cloning of th

• br Conflicts of interest br Acknowledgments

  2022-05-19

  

  Conflicts of interest Acknowledgments This work was supported by the following funds: National Natural Science Foundation of China (81502222); Natural Science Foundation of Hubei Province (2013CFB370); Training program for Wuhan young and middle-aged medical backbone personnel (2017–51). In

• br Some general considerations on

  2022-05-19

  

  Some general considerations on anterior pituitary cell type, models, sex and drugs Historically, real-time analysis of native endocrine anterior pituitary cell excitability has been somewhat limited and thus much of the pioneering work on anterior pituitary cell excitability and stimulus-secretio

• It has also been demonstrated that

  2022-05-19

  

  It has also been demonstrated that PS1 is ubiquitinated by Caenorhabditis elegans SEL-10 [52], Fbw7 the mammalian homologue of SEL-10 [38], and more recently by tumour necrosis factor anderson kpt associated factor 6 (TRAF6), which facilitates Lysine-63 (K63)-linked polyubiquitination of PS1 [50],

• br Novel mechanisms of fipronil

  2022-05-19

  

  Novel mechanisms of fipronil resistance in planthoppers Conclusion Conflict of interest Introduction Methamphetamine, a widely abused drug, is mainly used as a psychostimulant although it is occasionally used at low doses for medical purposes, such as in attention deficit or hyperactivit

• 9620 Since we were able to

  2022-05-19

  

  Since we were able to reach low micromolar to sub-micromolar potency in both compound series (6 and 7), we were also keen on assessing the preliminary ADME profile (particularly with respect to plasma and liver microsomal stability) of the most active compounds from these series. As it is evident fr

• Clinical data showed TAK was rapidly absorbed with

  2022-05-19

  

  Clinical data showed TAK-875 was rapidly absorbed with a half-life of 28-30h and clearance primarily through glucouronidation in the liver with minimal urinary clearance [30]. TAK-875 made the glycosylated hemoglobin (HbA1c) levels fall significantly from baseline after 24-week administration in onc

• Through the analysis of various

  2022-05-19

  

  Through the analysis of various synthetic GPR40 agonists as reported in literature, we found that a number of these compounds contained a phenylpropanoic g protein coupled receptors motif which was inspired from naturally occurring medium to long chain fatty acids. For instance, in the early period

• br Introduction Fructose bisphosphatase FBPase EC catalyses

  2022-05-19

  

  Introduction Fructose 1,6-bisphosphatase (FBPase; EC 3.1.3.11) catalyses the irreversible reaction of hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate [1]. Genetic and kinetic studies so far have demonstrated that at least two distinct isoenzymes of FBPase e

• Paroxysmal or sustained atrial fibrillations profoundly acti

  2022-05-19

  

  Paroxysmal or sustained atrial fibrillations profoundly activate platelets and induce coagulation factors in the heart (Choudhury and Lip, 2003). Accumulating factor Xa and downstream thrombin in the fibrillating left atrium activate PAR1 and/or PAR2 signaling to modulate electrical characteristics

• The combination of HIV antigen and

  2022-05-19

  

  The combination of HIV antigen and antibody testing with the fourth generation immunoassays shortens the window a66 for HIV by detecting HIV antigen, which appears in the blood before seroconversion [3,5,11,12]. Analysis of the seroconversion panels indicated the Elecsys® HIV Duo assay has a good se

• Here we examined Meckel s cartilage of

  2022-05-19

  

  Here, we examined Meckel's cartilage of mice where Setdb1 was knocked out only in neural crest derived M871 with the purpose of investigating the roles of Setdb1 in Meckel's cartilage, a supportive tissue for mandible formation. We observed enlarged Meckel's cartilage that was a result of increased

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