• These observations are of particular interest in the context

  2022-04-15

  

  These observations are of particular interest in the context of recent conceptual changes regarding the mechanisms by which different types of leukocytes contribute to atherogenesis. Over the last decade, the paradigm of the predominant circulatory origin of lesional macrophages has been challenged

• Previous studies have shown that

  2022-04-15

  

  Previous studies have shown that ox-LDL-induced hepatic sinus dysfunction is the result of multiple pathways, multi-factorial regulation, and in the present study, we reported for the first time that ox-LDL regulates the basement membrane protein VN through the integrin αvβ5 pathway under high gluco

• br Materials and methods br Results and discussion To

  2022-04-15

  

  Materials and methods Results and discussion To analyze the dependence of lysosomal exocytosis on Cu we exposed HeLa Cetylpyridinium Chloride to fresh buffer containing normal levels of free Ca (1mM) and measured β-hex levels in the extracellular medium, followed by measuring β-hex content in

• In this review we focus

  2022-04-15

  

  In this review, we focus on the structure and function of the KDM4A protein, its role in cancer development, and the importance of this enzyme as a therapeutic target. For further review of the KDM4 family, see Shi et al., Whetstine et al., and Berry et al. , , . KDM4A protein structure and enzymol

• We found that activator drugs decrease NOsGC

  2022-04-14

  

  We found that activator drugs decrease NOsGC protein levels in Sf9 cells. This decrease in protein levels is more pronounced for BAY 60–2770 compared to cinaciguat, and more obvious for α1/β1 compared to α2/β1 (see Fig. 2). This led us to hypothesize that the reduction in protein level correlates wi

• br Materials and methods br Results br Discussion Metabolic

  2022-04-14

  

  Materials and methods Results Discussion Metabolic abnormalities and systemic immune dysfunctions are common during HIV infection and/or antiretroviral therapy. Although some transcriptomic studies of HIV infection have revealed global changes in the mRNA and microRNA expression profiles (R

• Here we show that lactate activates the Gi

  2022-04-14

  

  Here we show that lactate activates the Gi-coupled receptor GPR81, which is exclusively expressed on adipocytes, and that lactate released from adipocytes in response to glucose and insulin mediates insulin-induced antilipolysis by activation of GPR81. Results Discussion Nutrients and their m

• The ER is responsible for

  2022-04-14

  

  The ER is responsible for calcium storage, lipid and protein biosynthesis, and the folding, assembly, and maturation of proteins [23], and ER stress is one of the main causes in T2DM, which leads to β-cell apoptosis and dysfunction [[5], [6], [7]]. In this study, TG was used as an ER stress inducer.

• br Conclusions Beta cell specific expression in human islets

  2022-04-14

  

  Conclusions Beta cell-specific expression in human islets of DGCR2, GBF1, GPR44 and SerpinB10 has not previously been described, although the proteins have partly been characterized in other contexts not related to beta 10537 synthesis or diabetes. DGCR2, GPR44 and SerpinB10 were negative in all

• br Conflict of interest statement br Acknowledgements

  2022-04-14

  

  Conflict of interest statement Acknowledgements We acknowledge the support of Zoetis Animal Health, Estrotect, Select Sires and Texas A&M AgriLife Research. The assistance of Randle Franke and Ernest Soto is also gratefully acknowledged. Background Luteal phase deficiency (LPD) is caused

• Next we designed substituents of the position Edge

  2022-04-14

  

  Next, we designed substituents of the 6-position. Edge-to-face aromatic interaction between aromatic ring of ligand and Phe162B needed to be retained because the interaction seems to be important for tight binding. 3′-Position of the 6-phenyl group of directs to a hydrophilic space where W1 exists.

• br Introduction Methylglyoxal MG is a

  2022-04-14

  

  Introduction Methylglyoxal (MG) is a highly reactive dicarbonyl metabolite formed in cells mainly by the spontaneous degradation of triose phosphates, glyceraldehyde-3-phosphate, and dihydroxyacetone phosphate (Rabbani and Thornalley, 2012). It exists in a wide range of organisms, including proto

• The study of TcMYH protein is a step forward for

  2022-04-14

  

  The study of TcMYH protein is a step forward for the characterization of a GO system in T. cruzi. The complete system appears to be present and our findings demonstrate that is important to maintain DNA stability of the nuclear and mitochondrial genomes, particularly in the presence of oxidative str

• AFB Fapy dG has been long recognized as a

  2022-04-14

  

  AFB1-Fapy-dG has been long recognized as a substrate for nucleotide excision repair [24,25]. However, we recently demonstrated that this lesion is removed by Pertussis Toxin synthesis excision repair. We showed that DNA glycosylase NEIL1, a member of the Fpg/Nei glycosylase family, could excise AFB

• L-Stepholidine australia HSOR belonging to the aldoketo redu

  2022-04-14

  

  3α-HSOR, belonging to the aldoketo reductase superfamily, is a rate-limiting enzyme for the synthesis of 3α-reduced steroids, such as allopregnanolone and tetrahydrodeoxycorticosterone. 3α-HSOR was extensively expressed in the spinal dorsal horn and was upregulated following peripheral nerve injury,

16180 records 483/1079 page Previous Next First page 上5页 481482483484485 下5页 Last page