• The chemical structure of BAs consists of a

  2022-01-04

  

  The chemical structure of BAs consists of a steroid nucleus with an acidic side chain. They are amphipatic molecules characterized by a hydrophilic α-face and a hydrophobic β-face. The hydrophobic pocket of the FXR LBD interacts with BAs largely through the β-face. The α-face contains several hydrox

• br Materials and methods br Results br Discussion Protein de

  2022-01-04

  

  Materials and methods Results Discussion Protein degradation plays a vital role in nearly all cellular processes, nearly 5% of genes are dedicated to the control of protein stability [31], [32]. The ubiquitin-proteasome system (UPS) represents the major way for degradation of proteins, wher

• br We are now ready to prove the

  2022-01-03

  

  We are now ready to prove the counterpart of Proposition 6.4 for κ-collectionwise normality. This is the pointfree counterpart of the classical result, originally proved in [23], that κ-collectionwise normality is hereditary with respect to -sets. (It may be worth emphasizing that the localic p

• Our study has strengths and limitations We believe

  2022-01-03

  

  Our study has strengths and limitations. We believe we are the 1st to report a novel model of secondary hypogonadism. Several animal models for hypogonadotropic hypogonadism (kisspeptin and the kisspeptin receptor knockout) exist but we are unaware of animal models of secondary hypogonadism with dif

• Finally it is possible that the increase in the

  2022-01-03

  

  Finally, it is possible that the increase in the number of EAAT-3-labelled cells in the DG at PD 60, when compared with the control and experimental animals at PD 14, is associated with natural changes in the number of neurons present during the postnatal development of the hippocampus (41, 42) and,

• m-Chlorophenylbiguanide hydrochloride australia In vitro stu

  2022-01-03

  

  In vitro studies have shown that some antidepressant drugs bind to NMDA receptors and inhibit the binding of NMDA receptor ligands [18]. Similarly, several research teams have reported that tricyclic antidepressants can modulate the release and/or uptake of glutamate [19]. In this study, we found th

• br Redox regulation in the

  2022-01-03

  

  Redox regulation in the brain Reactive oxygen species are generated in especially by the mitochondrial respiratory chain, which occurs on the inner mitochondrial membrane (Murphy, 2009, Jensen, 1966, Dickinson and Chang, 2011). Interestingly, although most cancer cells are thought to primarily r

• br Introduction Glucose homeostasis is primarily regulated

  2022-01-03

  

  Introduction Glucose homeostasis is primarily regulated by the hormones insulin and glucagon, secreted from the pancreatic islets of Langerhans. Although insulin produced by β jak stat inhibitor is the blood glucose-lowering hormone, glucagon secreted from α cells acts as the major counter-regul

• br Materials and methods br Results br Discussion Importantl

  2022-01-03

  

  Materials and methods Results Discussion Importantly, we observed that treatment with DA3-CH could reduce the pathophysiological processes in the hippocampal CA1 area after SE. At present, the unimolecular dual incretin receptor agonist has been developed as a treatment for type 2 diabetes,

• SQ 22536 Given the important role of Cx in

  2022-01-03

  

  Given the important role of Cx43 in maintaining the function of gap junctions, to investigate the effects of stress on Cx43 may be an important step towards understanding the mechanism underlying CUS-induced dysfunction of gap junctions. Corticosterone (CORT), as an important stress hormone, has bee

• The expression and localization of

  2022-01-03

  

  The expression and localization of Cx43, Cx46 and Cx50 in the anterior pituitary vary with physiological activities and with various conditions associated with both natural and pathological changes in hormone secretion. Anterior pituitary Cx43 and Cx50 levels increase and exhibit a more widespread d

• In total strains with relatively rapid acid

  2022-01-03

  

  In total, 5 strains with relatively rapid acid-producing ability (MA14, 15M2, DQHXNQ38–12, 5G2, and 6G5) were selected for further analysis. Compared with the strains ATCC19435, ZN8, and D-XJ4–12, which were used as controls, these 5 strains exhibited significantly different growth and titratable ac

• fatty acid amide hydrolase There are additional implications

  2022-01-03

  

  There are additional implications of α2-subunit alterations in the hippocampus. P has anticonvulsant activity (Herzog, 1995, Herzog et al., 1997, Herzog et al., 2012, Reddy et al., 2001, Reddy, 2010). These actions result from the metabolic conversion of P to GABA-A receptor-modulating, antiseizure

• An advantage of photolabeling with tritiated photoprobes

  2022-01-03

  

  An advantage of photolabeling with tritiated photoprobes followed by microsequencing with Edman degradation is the ability to both identify the photolabeled rilpivirine receptor and to quantify photoincorporation which enables assessment of pharmacological specificity and allosteric interactions wi

• br Experimental section br Acknowledgements This

  2022-01-03

  

  Experimental section Acknowledgements This study was supported by grants from the National Natural Science Foundation of China (Grants 81673299 and 81273376). Introduction Free fatty acids (FFAs) are important metabolic fuels and those that are polyunsaturated are essential components of t

16176 records 545/1079 page Previous Next First page 上5页 541542543544545 下5页 Last page